1. Explain the procedure for naming the coagulation factors.
2. List the principal coagulation factors.
3. Name the three groupings of coagulation factors and describe their similarities.
4. Describe the individual functional characteristics of each of the coagulation factors.
5. Name the four basic phases of blood coagulation.
6. Describe the sequence of events in the extrinsic pathway.
7. Describe the sequence of events in the intrinsic pathway.
8. Describe the sequence of events in the common coagulation pathway.
9. Describe the importance of vitamin K in hemostasis.
10. Define the term fibrinolysis, and describe the major components of fibrinolytic system and why fibrinolysis is necessary.
11. Describe the activities of antithrombin as a normal body defense mechanism.
12. Name the two heparin-dependent thrombin inhibitors and describe their role as part of the natural anticoagulant system.
13. Describe the functions of protein C and protein S.
14. Explain the activities of the cellular proteases and the role of specific body cells in the production of coagulation factors and cofactors.
15. Name and describe the assay techniques that can be used for the detection of fibrin split products.
16. What are the various categories of anticoagulant therapy and list some examples of each?
17. Compare the mechanisms of vitamin K, severe liver disease, and renal disease on defective blood coagulation factor production.
18. Compare and contrast the X-linked disorders of secondary hemostasis: actor VIII and factor IX deficiencies.
19. Describe the etiology, pathophysiology, and laboratory testing for congenital and acquired von Willebrand’s disorder.
20. Compare the laboratory findings for factor VIII and factor IX deficiencies and von Willebrand’s disease.
21. Give examples of uncommon coagulation factor deficiencies and describe conditions that contribute to the defective production of blood coagulation factors.
22. Define the term thrombophilia.
23. Explain the role of vascular damage and blood flow in the hypercoagulable state.
24. Detail how platelets contribute to hypercoagulation.
25. Compare the molecular and functional assays for diagnosis of antithrombin, protein C and protein S abnormalities.
26. Describe how activated protein C contributes to thrombophilia.
27. Describe the activity of blood coagulation factors in increasing the tendency toward thrombosis.
28. Explain the characteristic and laboratory findings in antiphospholipid syndrome.
29. Describe the relationship between impaired fibrinolysis and protein C, antithrombin, and plasminogen.
30. Describe the laboratory assessments that illustrate the condition of hypercoagulation.
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