$20 Bonus + 25% OFF
Securing Higher Grades Costing Your Pocket?
Book Your Assignment at The Lowest Price
Now!
Students Who Viewed This Also Studied
BIOLOGY 20 General Biology
Task:
Introduction
Daily more than a million people are infected with any of the four distinct serotypes of dengue viruses (DENV-1, −2, −3, and, −4). The world needs a dengue vaccine for all age groups, regardless of whether they may, or may not have been previously exposed to one of the four dengue viruses. In 2019, Sanofi Pasteur’s Dengvaxia, a live attenuated tetravalent dengue vaccine, whichdoes not give complete protection, after a three-dose regimen spread over 1 year (Arredondo-García et al., 2018; Thomas and Y oon, 2019), was granted a limited approval by the United States Food and Drug Administration. This approval was for its use in 9–16 year-old children with laboratory-confirmed previous dengue infection, living in dengue-endemic areas (United States Food & Drug, 2019). Efficacy trials of Dengvaxia in several dengue-endemic countries of Asia and Latin America, in ∼35,000 2–16 year-old children (Sabchareon et al., 2012; Capeding et al., 2014; Villar et al., 2015), showed that vaccine efficacy (VE) i.e., the capacity to prevent symptomatic virologically confirmed dengue (VCD), varied by serotype, and was the lowest against DENV2. Overall VE was 65.6% (95% CI 60.7–69.9) in 9–16 year olds, while in 2–8 year olds it was 44.6% (95% CI 31.6–55), at 2 years following administration of the first dose of the vaccine. At 3 years post-dose 1, vaccinated children in the 2–5 year age group, were found to be nearly 8 times likely to be hospitalized for severe dengue, compared to children in the placebo group (Hadinegoro et al., 2015). VE was subsequently found to be related to the pre-vaccination serostatus of the trial subjects.
While VE against VCD at 2 years post-dose 1 was 76% (95% CI 64–84) in >9 year-old children, who had been exposed to dengue infection before vaccination (seropositive), it was only 39% (95% CI−1 to 63) in children who were dengue-naïve (seronegative) at the beginning of the trial (Sridhar et al., 2018). Long-term follow-up studies until 5 years reveal that in seronegative recipients, there is increased risk of severe dengue from the 3rd year onwards, postdose 1. Clearly, developing a safe and efficacious dengue vaccine constitutes quite a formidable challenge. Several unique factors, associated with the biology, and pathogenesis of dengue, taken together with lessons of the Dengvaxia experience, necessitates exploring alternate dengue vaccine development options.
There are additional whole virus-based dengue vaccines in advance stages of clinical trials (Clinicaltrials.gov, 2020; Tricou et al., 2020). Moreover, a few recombinant dengue vaccine candidates are also at various stages of development (Vannice et al., 2015; Swaminathan and Khanna, 2019; Deng et al., 2020). It is great that the pipeline of dengue vaccines continue to increase. A safe and effective dengue vaccine could soon become a reality.
BIOLOGY 20 General Biology
Answer in Detail
Solved by qualified expert
Get Access to This Answer
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Hac habitasse platea dictumst vestibulum rhoncus est pellentesque. Amet dictum sit amet justo donec enim diam vulputate ut. Neque convallis a cras semper auctor neque vitae. Elit at imperdiet dui accumsan. Nisl condimentum id venenatis a condimentum vitae sapien pellentesque. Imperdiet massa tincidunt nunc pulvinar sapien et ligula. Malesuada fames ac turpis egestas maecenas pharetra convallis posuere. Et ultrices neque ornare aenean euismod. Suscipit tellus mauris a diam maecenas sed enim. Potenti nullam ac tortor vitae purus faucibus ornare. Morbi tristique senectus et netus et malesuada. Morbi tristique senectus et netus et malesuada. Tellus pellentesque eu tincidunt tortor aliquam. Sit amet purus gravida quis blandit. Nec feugiat in fermentum posuere urna. Vel orci porta non pulvinar neque laoreet suspendisse interdum. Ultricies tristique nulla aliquet enim tortor at auctor urna. Orci sagittis eu volutpat odio facilisis mauris sit amet.
Tellus molestie nunc non blandit massa enim nec dui. Tellus molestie nunc non blandit massa enim nec dui. Ac tortor vitae purus faucibus ornare suspendisse sed nisi. Pharetra et ultrices neque ornare aenean euismod. Pretium viverra suspendisse potenti nullam ac tortor vitae. Morbi quis commodo odio aenean sed. At consectetur lorem donec massa sapien faucibus et. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Duis at tellus at urna condimentum mattis pellentesque. Vivamus at augue eget arcu dictum varius duis at. Justo donec enim diam vulputate ut. Blandit libero volutpat sed cras ornare arcu. Ac felis donec et odio pellentesque diam volutpat commodo. Convallis a cras semper auctor neque. Tempus iaculis urna id volutpat lacus. Tortor consequat id porta nibh.
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Hac habitasse platea dictumst vestibulum rhoncus est pellentesque. Amet dictum sit amet justo donec enim diam vulputate ut. Neque convallis a cras semper auctor neque vitae. Elit at imperdiet dui accumsan. Nisl condimentum id venenatis a condimentum vitae sapien pellentesque. Imperdiet massa tincidunt nunc pulvinar sapien et ligula. Malesuada fames ac turpis egestas maecenas pharetra convallis posuere. Et ultrices neque ornare aenean euismod. Suscipit tellus mauris a diam maecenas sed enim. Potenti nullam ac tortor vitae purus faucibus ornare. Morbi tristique senectus et netus et malesuada. Morbi tristique senectus et netus et malesuada. Tellus pellentesque eu tincidunt tortor aliquam. Sit amet purus gravida quis blandit. Nec feugiat in fermentum posuere urna. Vel orci porta non pulvinar neque laoreet suspendisse interdum. Ultricies tristique nulla aliquet enim tortor at auctor urna. Orci sagittis eu volutpat odio facilisis mauris sit amet.
Tellus molestie nunc non blandit massa enim nec dui. Tellus molestie nunc non blandit massa enim nec dui. Ac tortor vitae purus faucibus ornare suspendisse sed nisi. Pharetra et ultrices neque ornare aenean euismod. Pretium viverra suspendisse potenti nullam ac tortor vitae. Morbi quis commodo odio aenean sed. At consectetur lorem donec massa sapien faucibus et. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Duis at tellus at urna condimentum mattis pellentesque. Vivamus at augue eget arcu dictum varius duis at. Justo donec enim diam vulputate ut. Blandit libero volutpat sed cras ornare arcu. Ac felis donec et odio pellentesque diam volutpat commodo. Convallis a cras semper auctor neque. Tempus iaculis urna id volutpat lacus. Tortor consequat id porta nibh.
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Hac habitasse platea dictumst vestibulum rhoncus est pellentesque. Amet dictum sit amet justo donec enim diam vulputate ut. Neque convallis a cras semper auctor neque vitae. Elit at imperdiet dui accumsan. Nisl condimentum id venenatis a condimentum vitae sapien pellentesque. Imperdiet massa tincidunt nunc pulvinar sapien et ligula. Malesuada fames ac turpis egestas maecenas pharetra convallis posuere. Et ultrices neque ornare aenean euismod. Suscipit tellus mauris a diam maecenas sed enim. Potenti nullam ac tortor vitae purus faucibus ornare. Morbi tristique senectus et netus et malesuada. Morbi tristique senectus et netus et malesuada. Tellus pellentesque eu tincidunt tortor aliquam. Sit amet purus gravida quis blandit. Nec feugiat in fermentum posuere urna. Vel orci porta non pulvinar neque laoreet suspendisse interdum. Ultricies tristique nulla aliquet enim tortor at auctor urna. Orci sagittis eu volutpat odio facilisis mauris sit amet.
Tellus molestie nunc non blandit massa enim nec dui. Tellus molestie nunc non blandit massa enim nec dui. Ac tortor vitae purus faucibus ornare suspendisse sed nisi. Pharetra et ultrices neque ornare aenean euismod. Pretium viverra suspendisse potenti nullam ac tortor vitae. Morbi quis commodo odio aenean sed. At consectetur lorem donec massa sapien faucibus et. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Duis at tellus at urna condimentum mattis pellentesque. Vivamus at augue eget arcu dictum varius duis at. Justo donec enim diam vulputate ut. Blandit libero volutpat sed cras ornare arcu. Ac felis donec et odio pellentesque diam volutpat commodo. Convallis a cras semper auctor neque. Tempus iaculis urna id volutpat lacus. Tortor consequat id porta nibh.
13 More Pages to Come in This Document. Get access to the complete answer.
More BIOLOGY20 BIOLOGY 20 General Biology: Questions & Answers
ARCL 140 – Bones: The Origins of Humanity
1. Compare the lower dentition of H. habilis with that of the australopithecine in the lab. How are they different? (make sure to consider the scale).2. Compare the H. habilis cranium with that of A. africanus and P. boisei in the lab. How are they different?3. Observe the H. heidelbergensis skull i …
View Answer
92542 Applied Biomechanics
Task:
PurposeThe purpose of the research proposal is for students to provide background information to justify their research topic, develop their research question, and propose methodology to answer their research question.Brief literature review (500 words):1. Include a summary of the literatur …
View Answer
Science
How to stabilize clay soil to make clay soil non dispersive. …
View Answer
LAW72017 DNA & The Law
The journal articles relate to challenges and opportunities that may impact on the future of forensic DNA. The articles explore potential developments and their impact on the justice system.You are required in this assessment to select one of the three journal articles and to describe, analyse and c …
View Answer
Content Removal Request
If you are the original writer of this content and no longer wish to have your work published on Myassignmenthelp.com then please raise the
content removal request.
Choose Our Best Expert to Help You
Still in Two Minds? The Proof is in Numbers!
33845 Genuine Reviews With a Rating of 4.9/5.
Economics
Assignment: 28 Pages, Deadline:
6 days
Thanks for all the effort, the only concern or question is, how would be possible to do any revision in future if needed?
User ID: 8***91 Canada
Civil Law
Assignment: 0 Pages, Deadline:
20 days
The presentation is well executed generally. The style (delivery) could be more engaging with the listening audience. The slides are good – concise an …
User ID: 3***07 Cork, Ireland
Electronics
Home Work: 6 Pages, Deadline:
9 hours
Awesome Stuff! They provided really useful feedback and helped me understand the assignment very well.
User ID: 5***73 United Kingdom, Great Britain
Audit
Assignment: 14 Pages, Deadline:
13 days
The assignment has not been scored yet but thank you for the corrections and time.
User ID: 8***91 United Kingdom, Great Britain
Management
Assignment: 12 Pages, Deadline:
2 days
I have been quite a good experience with your service. I got 70/100 grade on my result. However, the most important things that you can do are more cr …
User ID: 8***43 United Kingdom, Singapore
Nursing
Assignment: 5 Pages, Deadline:
16 days
This was my last assignment for concepts and theories class and when I tell you using this site helped while I was in school and in between classes.
User ID: 6***42 United Kingdom, United States
Healthcare
Essay: 6 Pages, Deadline:
12 days
Received a good grade for this particular assignment. It was on time and informative with the topic provided. Thank you.
User ID: 6***42 United Kingdom, United States
Medical
Course Work: 4 Pages, Deadline:
6 days
Thanks it’s a great jobWaiting for the result from the teacherI will definitely deal with you in the coming days
User ID: 8***67 Belfast, Great Britain
Assignment
Essay: 2 Pages, Deadline:
7 hours
Amazing work done in spam of 6 hours. Great quality, best price. I have used this platform multiple times on all my english assignment and have always …
User ID: 8***85 Belfast, United States
Marketing
Home Work: 6 Pages, Deadline:
3 days
Good starting work for guidance – gives student time to revfine and add more input after understanding the framework/.
User ID: 8***39 Belfast, Malaysia
Finance
Home Work: 1 Page, Deadline:
14 days
Thank you so much! This was my first assignment which is I asked for help from here, and I will keep working with them. I’m so satisfied.
User ID: 8***99 Belfast, Austria
Assignment
Essay: 4.8 Pages, Deadline:
18 days
Amazing work, very happy. Will definitely recommend. Very precise, the topics very well presented. References in order, will have to wait until it wil …
User ID: 8***08 United Kingdom, Great Britain
Marketing
Thesis: 5 Pages, Deadline:
4 days
The work is legendary in every sense of the wordThank you, expert, for this wonderful work. Thank you for your effortIndeed, I am completely satisfied …
User ID: 9***3 United Kingdom, Kuwait
Statistics
Programming: 1.4 Pages, Deadline:
5 days
Excellent and very happy with the work. Would recommend to my friends and family.
User ID: 8***32 United Kingdom, Singapore
Management
Assignment: 7.6 Pages, Deadline:
9 days
Thank you very much for the good work and rework. I make this opportunity say happy new year for all of you and I would like to make use of service fu …
User ID: 7***46 United Kingdom, Saudi Arabia
Psychology
Home Work: 8 Pages, Deadline:
19 hours
It was perfect :); The answers are well structured. and as instructed, the work was submitted on time
User ID: 8***28 Malé, Maldives
Nursing
Essay: 6 Pages, Deadline:
3 days
Expert is nice and efficiency. Good communication with me and fast reply. Admin and call center is very helpful.
User ID: 2***16 Central, Hong Kong
It Write Up
Home Work: 1 Page, Deadline:
6 days
Didnt receive much marks. i dont know why. Maybe they didnt do well but that was just enouogh
User ID: 3***70 Central, Australia
Accounting
Course Work: 7 Pages, Deadline:
19 days
Happy with the outcome. Nice and easy to deal with and get started. delivered to timeframe and general expectations. Thank you and always a pleasure d …
User ID: 5***39 United Kingdom, Great Britain
Ancient History
Essay: 1 Page, Deadline:
9 days
thank you so much, work done on time, I appreciatedthank you so much to the person that did it
User ID: 4***45 United Kingdom, Australia
Economics
Assignment: 28 Pages, Deadline:
6 days
Thanks for all the effort, the only concern or question is, how would be possible to do any revision in future if needed?
User ID: 8***91 Canada
Civil Law
Assignment: 0 Pages, Deadline:
20 days
The presentation is well executed generally. The style (delivery) could be more engaging with the listening audience. The slides are good – concise an …
User ID: 3***07 Cork, Ireland
Electronics
Home Work: 6 Pages, Deadline:
9 hours
Awesome Stuff! They provided really useful feedback and helped me understand the assignment very well.
User ID: 5***73 United Kingdom, Great Britain
Audit
Assignment: 14 Pages, Deadline:
13 days
The assignment has not been scored yet but thank you for the corrections and time.
User ID: 8***91 United Kingdom, Great Britain
Management
Assignment: 12 Pages, Deadline:
2 days
I have been quite a good experience with your service. I got 70/100 grade on my result. However, the most important things that you can do are more cr …
User ID: 8***43 United Kingdom, Singapore
Nursing
Assignment: 5 Pages, Deadline:
16 days
This was my last assignment for concepts and theories class and when I tell you using this site helped while I was in school and in between classes.
User ID: 6***42 United Kingdom, United States
Healthcare
Essay: 6 Pages, Deadline:
12 days
Received a good grade for this particular assignment. It was on time and informative with the topic provided. Thank you.
User ID: 6***42 United Kingdom, United States
Medical
Course Work: 4 Pages, Deadline:
6 days
Thanks it’s a great jobWaiting for the result from the teacherI will definitely deal with you in the coming days
User ID: 8***67 Belfast, Great Britain
Assignment
Essay: 2 Pages, Deadline:
7 hours
Amazing work done in spam of 6 hours. Great quality, best price. I have used this platform multiple times on all my english assignment and have always …
User ID: 8***85 Belfast, United States
Marketing
Home Work: 6 Pages, Deadline:
3 days
Good starting work for guidance – gives student time to revfine and add more input after understanding the framework/.
User ID: 8***39 Belfast, Malaysia
Finance
Home Work: 1 Page, Deadline:
14 days
Thank you so much! This was my first assignment which is I asked for help from here, and I will keep working with them. I’m so satisfied.
User ID: 8***99 Belfast, Austria
Assignment
Essay: 4.8 Pages, Deadline:
18 days
Amazing work, very happy. Will definitely recommend. Very precise, the topics very well presented. References in order, will have to wait until it wil …
User ID: 8***08 United Kingdom, Great Britain
Marketing
Thesis: 5 Pages, Deadline:
4 days
The work is legendary in every sense of the wordThank you, expert, for this wonderful work. Thank you for your effortIndeed, I am completely satisfied …
User ID: 9***3 United Kingdom, Kuwait
Statistics
Programming: 1.4 Pages, Deadline:
5 days
Excellent and very happy with the work. Would recommend to my friends and family.
User ID: 8***32 United Kingdom, Singapore
Management
Assignment: 7.6 Pages, Deadline:
9 days
Thank you very much for the good work and rework. I make this opportunity say happy new year for all of you and I would like to make use of service fu …
User ID: 7***46 United Kingdom, Saudi Arabia
Psychology
Home Work: 8 Pages, Deadline:
19 hours
It was perfect :); The answers are well structured. and as instructed, the work was submitted on time
User ID: 8***28 Malé, Maldives
Nursing
Essay: 6 Pages, Deadline:
3 days
Expert is nice and efficiency. Good communication with me and fast reply. Admin and call center is very helpful.
User ID: 2***16 Central, Hong Kong
It Write Up
Home Work: 1 Page, Deadline:
6 days
Didnt receive much marks. i dont know why. Maybe they didnt do well but that was just enouogh
User ID: 3***70 Central, Australia
Accounting
Course Work: 7 Pages, Deadline:
19 days
Happy with the outcome. Nice and easy to deal with and get started. delivered to timeframe and general expectations. Thank you and always a pleasure d …
User ID: 5***39 United Kingdom, Great Britain
Ancient History
Essay: 1 Page, Deadline:
9 days
thank you so much, work done on time, I appreciatedthank you so much to the person that did it
User ID: 4***45 United Kingdom, Australia
