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BIOL UN3799 Molecular Biology of Cancer
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Case study #2 Assignment
Approximately, 20% of all fatal cancers are caused by infectious agents (most viruses), which include a broad range of neoplastic diseases (lymphomas, cervical cancer, liver cancer, etc.). In this case we will focus on Human Papillomavirus (HPV), a small DNA virus responsible for over 99% of all cervical cancer (can also cause other cancers in immunocompromised patients too).
The optimal management of cervical cancer consists of prevention (Pap smears or VIA screening) and vaccination. In a disease caused by sexual transmission an appealing strategy is to vaccinate populations that are prior to start of sexual activity. This aims to prevent rather than merely control or treat cervical cancer.
Case Study: Pamela Johnson, a 38-year-old women with abnormal Pap smear findings.
Pamela Johnson is a middle school math teacher, she lives with her husband and they have been married for 15 years. She has an 11-year-old daughter and a 9-year-old son. During her annual physical exam, she had a routine Pap smear that showed evidence of cell dysplasia, classified as cervical intraepithelial neoplasia, grade II. Her doctor advised her to undergo a look electrosurgical excision procedure (LEEP), an outpatient procedure only requiring local anethetic taking less than an hour. The doctor advised her to have LEEP to prevent progression to cancer.
When the doctor asked if she had any questions she had the following questions that maybe you can help answer for Pamela:
Answer the following questions below1-7 and make sure to explain Each question in depth
1) Pamela heard that cervical cancer was caused by HPV, should she have her daughter vaccinated?
2) Does the vaccine fully protect her from getting cervical cancer?
3) Will it make it so her daughter does not have to get Pap smears?
4) Why does her daughter have to get it done as a teen when she has not heard of a teen with cervical cancer?
5) Would it be good for her son to get the vaccine too?
6) Is the vaccine made of virus particles that can infect her children with the virus? In your answers try to find scientific data to answer her questions and cite the sources.
In your answers makes sure to give details that will help back your claims. Talk about HPV, the vaccine, and how the virus causes cancer too.
BIOL UN3799 Molecular Biology of Cancer
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