Describe the cause and incidence of CF. What are the symptoms and the pathogenesis of disease described in Figure 1.
When was the gene responsible for CF identified? What does CFTR do? Describe in detail the six functional classes of CF mutations (Figure 2).
What does the author argue about the characterization of CF as a simple, monogenic disease?
Explain how the concept of personalized medicine could be used in the treatment of CF. (Include in your answer a description of types of therapies used to treat CF.)
