$20 Bonus + 25% OFF
Securing Higher Grades Costing Your Pocket?
Book Your Assignment at The Lowest Price
Now!
Students Who Viewed This Also Studied
B940 Biomedical Science
Question :
Case Study 1
A 40-year-old man presented with headache, nausea and visual complaints. A large enhancing lesion in the right frontal lobe was identified by magnetic resonance imaging (MRI) and the patient underwent debulking surgery. Histopathology and molecular genetic analysis of IDH1 and co-deletion of chromosomes 1p and 19 q status of the resected tissue revealed features consistent with the diagnosis of an oligodendroglioma. The patient was treated with a combination therapy of radiation and chemotherapy for a period of 4-5 weeks.
Case Study 2
A female patient was diagnosed with Non-Hodgkins lymphoma at six years of age and at age 13 presented with rectal bleeding. A colectomy was performed after a mass was identified by a colonoscopy. Her consanguineous parents (2nd degree cousins) reported a colorectal cancer in a paternal uncle, and he was diagnosed at the age of 43 years with synchronous adenocarcinomas in the sigmoid and descending colon.
Microsatellite Instability (MSI) analysis and immunohistochemical (IHC) analysis of MMR proteins shows high MSI and loss of hMHS6 in non-malignant and malignant cells of the colonic mucosa. Sequence analysis of hMSH6 in the index patient displayed a homozygous single nucleotide deletion in exon 4 (c.691delG) leading to a frameshift and premature termination (p.Val231TyrfsX15).
Case Study 3
A 30-year old woman attended for routine cervical screening. Her sample was reported as mild squamous cell dyskaryosis. HPV testing was performed on the sample. As a result of the outcome of the HPV test the woman was referred to colposcopy for further investigation. A large loop excision of the transformation zone was performed due to a suspicious area being identified on the cervix. The tissue was sent to histology for processing and reporting.
Case Study 4
A 4-year old child was referred to a Consultant Nephrologist and following testing, the diagnosis was returned as inconclusive. It was thought possible that the child might be suffering either from Autosomal Dominant Polycystic Kidney Disease (ADPKD) or Autosomal Recessive Polycystic Kidney Disease (ARPKD), both of which are ciliopathies.
Questions – Answer ALL questions
With reference to Case study 1, using a minimum of 5 references and a 750 maximum word limit for the case study, answer the following questions. (Total 25 marks)
1. In the case study the patient was diagnosed with an oligodendroglioma.
Describe 2 of the additional molecular alterations that frequently occur in this type of tumour. Explain how they are assessed and outline the microscopic (histological) features that are associated with a diagnosis of a grade II oligodendroglioma. (15 marks)
2. In the case study, the patient was diagnosed with an oligodendroglioma. Would this tumour have mutant IDH1? Describe how the status of IDH1could be determined. How is this relevant to therapy? (10 marks)
With reference to Case study 2, using a minimum of 5 references and a 750 maximum word limit for the case study, answer the following questions.
Microsatellite instability is seen in approximately 15% of sporadic cancers.
What tests can be used to confirm protein loss? (4 marks)
1. DNA Mismatch Repair is also compromised in HNPCC. Explain the cause of HNPCC. (4 marks)
2. What is a homozygous deletion? (4 marks)
3. In what aspect of DNA MMR is hMHS6 involved? (3 marks)
4. What other forms of DNA repair exist? (5 marks)
5. Sequence analysis was used to identify the causative mutation. Briefly state any indirect approaches to mutation detection. (5 marks)
With Reference to Case study 3, using a minimum of 5 references and a 750 maximum word limit for the case study, answer the following questions.(Total 25 marks)
Explain the adaptive process that takes place in the transformation zone that makes the cells more susceptible to the development of cervical disease.
Fixation is an important step in the preparation of tissues for histological samples. Tissues are then processed through to wax blocks.
1. Describe the steps involved in tissue processing and discuss the role of each stage and the reagents used.
2. Discuss what forms of quality control would be involved in the laboratory.
With Reference to Case study 3, using a minimum of 5 references and a 750 maximum word limit for the case study, answer the following questions.(Total 25 marks)
Discuss the molecular and cellular characteristics that resulted in ARPKD being classified as a ciliopathy.
Discuss the personalised medicine approaches that could help ensure an accurate diagnosis for this patient.
B940 Biomedical Science
Answer in Detail
Solved by qualified expert
Get Access to This Answer
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Hac habitasse platea dictumst vestibulum rhoncus est pellentesque. Amet dictum sit amet justo donec enim diam vulputate ut. Neque convallis a cras semper auctor neque vitae. Elit at imperdiet dui accumsan. Nisl condimentum id venenatis a condimentum vitae sapien pellentesque. Imperdiet massa tincidunt nunc pulvinar sapien et ligula. Malesuada fames ac turpis egestas maecenas pharetra convallis posuere. Et ultrices neque ornare aenean euismod. Suscipit tellus mauris a diam maecenas sed enim. Potenti nullam ac tortor vitae purus faucibus ornare. Morbi tristique senectus et netus et malesuada. Morbi tristique senectus et netus et malesuada. Tellus pellentesque eu tincidunt tortor aliquam. Sit amet purus gravida quis blandit. Nec feugiat in fermentum posuere urna. Vel orci porta non pulvinar neque laoreet suspendisse interdum. Ultricies tristique nulla aliquet enim tortor at auctor urna. Orci sagittis eu volutpat odio facilisis mauris sit amet.
Tellus molestie nunc non blandit massa enim nec dui. Tellus molestie nunc non blandit massa enim nec dui. Ac tortor vitae purus faucibus ornare suspendisse sed nisi. Pharetra et ultrices neque ornare aenean euismod. Pretium viverra suspendisse potenti nullam ac tortor vitae. Morbi quis commodo odio aenean sed. At consectetur lorem donec massa sapien faucibus et. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Duis at tellus at urna condimentum mattis pellentesque. Vivamus at augue eget arcu dictum varius duis at. Justo donec enim diam vulputate ut. Blandit libero volutpat sed cras ornare arcu. Ac felis donec et odio pellentesque diam volutpat commodo. Convallis a cras semper auctor neque. Tempus iaculis urna id volutpat lacus. Tortor consequat id porta nibh.
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Hac habitasse platea dictumst vestibulum rhoncus est pellentesque. Amet dictum sit amet justo donec enim diam vulputate ut. Neque convallis a cras semper auctor neque vitae. Elit at imperdiet dui accumsan. Nisl condimentum id venenatis a condimentum vitae sapien pellentesque. Imperdiet massa tincidunt nunc pulvinar sapien et ligula. Malesuada fames ac turpis egestas maecenas pharetra convallis posuere. Et ultrices neque ornare aenean euismod. Suscipit tellus mauris a diam maecenas sed enim. Potenti nullam ac tortor vitae purus faucibus ornare. Morbi tristique senectus et netus et malesuada. Morbi tristique senectus et netus et malesuada. Tellus pellentesque eu tincidunt tortor aliquam. Sit amet purus gravida quis blandit. Nec feugiat in fermentum posuere urna. Vel orci porta non pulvinar neque laoreet suspendisse interdum. Ultricies tristique nulla aliquet enim tortor at auctor urna. Orci sagittis eu volutpat odio facilisis mauris sit amet.
Tellus molestie nunc non blandit massa enim nec dui. Tellus molestie nunc non blandit massa enim nec dui. Ac tortor vitae purus faucibus ornare suspendisse sed nisi. Pharetra et ultrices neque ornare aenean euismod. Pretium viverra suspendisse potenti nullam ac tortor vitae. Morbi quis commodo odio aenean sed. At consectetur lorem donec massa sapien faucibus et. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Duis at tellus at urna condimentum mattis pellentesque. Vivamus at augue eget arcu dictum varius duis at. Justo donec enim diam vulputate ut. Blandit libero volutpat sed cras ornare arcu. Ac felis donec et odio pellentesque diam volutpat commodo. Convallis a cras semper auctor neque. Tempus iaculis urna id volutpat lacus. Tortor consequat id porta nibh.
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Hac habitasse platea dictumst vestibulum rhoncus est pellentesque. Amet dictum sit amet justo donec enim diam vulputate ut. Neque convallis a cras semper auctor neque vitae. Elit at imperdiet dui accumsan. Nisl condimentum id venenatis a condimentum vitae sapien pellentesque. Imperdiet massa tincidunt nunc pulvinar sapien et ligula. Malesuada fames ac turpis egestas maecenas pharetra convallis posuere. Et ultrices neque ornare aenean euismod. Suscipit tellus mauris a diam maecenas sed enim. Potenti nullam ac tortor vitae purus faucibus ornare. Morbi tristique senectus et netus et malesuada. Morbi tristique senectus et netus et malesuada. Tellus pellentesque eu tincidunt tortor aliquam. Sit amet purus gravida quis blandit. Nec feugiat in fermentum posuere urna. Vel orci porta non pulvinar neque laoreet suspendisse interdum. Ultricies tristique nulla aliquet enim tortor at auctor urna. Orci sagittis eu volutpat odio facilisis mauris sit amet.
Tellus molestie nunc non blandit massa enim nec dui. Tellus molestie nunc non blandit massa enim nec dui. Ac tortor vitae purus faucibus ornare suspendisse sed nisi. Pharetra et ultrices neque ornare aenean euismod. Pretium viverra suspendisse potenti nullam ac tortor vitae. Morbi quis commodo odio aenean sed. At consectetur lorem donec massa sapien faucibus et. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Duis at tellus at urna condimentum mattis pellentesque. Vivamus at augue eget arcu dictum varius duis at. Justo donec enim diam vulputate ut. Blandit libero volutpat sed cras ornare arcu. Ac felis donec et odio pellentesque diam volutpat commodo. Convallis a cras semper auctor neque. Tempus iaculis urna id volutpat lacus. Tortor consequat id porta nibh.
25 More Pages to Come in This Document. Get access to the complete answer.
Our qualified team of writers constitutes the firm pillar of success. MyAssignmenthelp.com gives you the opportunity to reach a step ahead in success with quality assignments. We encompass UK, US and Australia along with an expansion to Canada, Singapore and UAE. Feel blessed to get your assignments tailored by our PhD qualified authors with guaranteed high marks. With years of experience in the industry, we are eligible to handle any project, any topic within the stipulated time. MyAssignmenthelp.com is the most trusted brand and takes minimum turnaround time for each order. Custom essay help, online assignment help and dissertation writing services are our primary course of services. We are available 24*7 to accommodate your queries round the clock.
More B940 B940 Biomedical Science: Questions & Answers
ANTH 1 Introduction to Anthropology
Task
Poem (Quiz)
Due Tuesday by 11:59pm
Points 10
Submitting a text entry box, a website url, a media recording, or a file upload
Available Nov 19 at 12am – Nov 30 at 11:59pm 12 days
Please check out the YouTube video with verbal instructions on the Poem Quiz.
Start Assign …
View Answer
Business Management
Choose one major environmental issue that has national and Global implications. For this issue, develop a Policy Initiative for a private organisation. In this, Initiative: 1. Describe the function(s) of the organisation 2. Data justifying the need for the Initiative 3. …
View Answer
XNB272 Biomechanics
Question:
What you need to do:
For a human movement, exercise or sports skill of your choice:
1. Identify the goals of the skill.
2. Identify and explain the biomechanical principles that are applied to achieve the goals.
3. Identify the critical features (minimum of 2 qualita …
View Answer
Management
Research Report The chances of developing cancer are fairly high, and cancer is very much a current real world issue. Almost everyone has been affected by cancer in some way or knows someone who has been. This research report will have you explore the type of cancer you selected in Unit III. Acute L …
View Answer
Content Removal Request
If you are the original writer of this content and no longer wish to have your work published on Myassignmenthelp.com then please raise the
content removal request.
Choose Our Best Expert to Help You
Chloe Baldwin
PhD in Physics with Specialization in Classical Physics
2971 – Completed Orders
Hire Me
Koen Warner
Ph.D. in University At Buffalo, The State University of New York
500 – Completed Orders
Hire Me
Still in Two Minds? The Proof is in Numbers!
33845 Genuine Reviews With a Rating of 4.9/5.
Programing
Programming: 1 Page, Deadline:
10 days
thanks i had a good grade although it took so many back and forth i hope it wont happen again
User ID: 6***09 Philippines
Healthcare
Assignment: 1 Page, Deadline:
9 hours
Thanks for helping me understand my assignment and also helping me with the write up.
User ID: 8***87 United States
Accounting
Programming: 6.4 Pages, Deadline:
6 days
Excellent Service, Professional and Complete Writing. Will sure contact for further future assignments.
User ID: 8***38 Australia
Finance
Home Work: 2 Pages, Deadline:
3 days
Thankfully, I received one of the best marks awarded for the kind of work given. I am grateful to my assignment help team for their assistance
User ID: 2***85 Ghana
Business Law
Home Work: 1 Page, Deadline:
1 hour
Thank you for your service. Really appreciate that you make my assignment within time
User ID: 7***52 Canada
Management
Assignment: 2 Pages, Deadline:
7 days
Thank you Expert, my professor regraded my work and gave me a good grade this time. but he also mention that going forward i should be more detailed i …
User ID: 2***97 Upper Marlboro, United States
Medical
Programming: 4 Pages, Deadline:
4 days
Really thanks to your efforts. excellent work. It’s well written and well organized and well explained as following instructions. Thanks a lot.
User ID: 6***55 Upper Marlboro, Canada
Marketing
Assignment: 3 Pages, Deadline:
4 days
Well I must say I was delighted by the timelines and great work. The assignment was top notch with excellent results. I got a A+!!!!!
User ID: 8***30 Upper Marlboro, United States
Economics
Home Work: 1 Page, Deadline:
2 days
Great performance by expert which got reflected on the result 9/10. Iam totally satisfied by the performance and result.
User ID: 8***42 Upper Marlboro, Bahrain
Management
Assignment: 6 Pages, Deadline:
1 day
The writer did an amazing job I am pleased with it gave the work to me in time I am happy with it will do more works with them
User ID: 3***40 Chennai, Great Britain
Economics
Programming: 10 Pages, Deadline:
16 days
A legend, a legend, dear expert. The work is excellent and distinct. It contains all the important and accurate details. I thank you for the professio …
User ID: 9***3 Chennai, Kuwait
Nursing
Essay: 8 Pages, Deadline:
12 days
Excellent work! I attained HD on the subject and is one of my highest scores. Thank You!!!
User ID: 6***30 Chennai, Australia
Civil Engineering
Programming: 16 Pages, Deadline:
20 days
was able to submit my assignment early. happy with the service provided. Will use this platform often if i need any other assignments done.
User ID: 7***56 Chennai, Singapore
Nursing
Assignment: 4 Pages, Deadline:
30 days
The paper shows a good grasp of some of the basic points made in the literature, weaving together a number of overlapping ideas.
User ID: 7***96 Chennai, United States
Healthcare
Essay: 4 Pages, Deadline:
18 days
I hope in my next coming assignment you can improve more in order to excellent in A . Thank you for your hard work
User ID: 7***47 Chennai, Singapore
Civil Law
Home Work: 4 Pages, Deadline:
5 hours
Thanks a lot for a quality work I like this expert’s writing structure. I always get help from this site. Customer services is also very good.
User ID: 7***54 Blackburn, Great Britain
Finance
Home Work: 2 Pages, Deadline:
8 days
I will let you know when I receive my grade for the Unit 4 Discussion Board assignment.
User ID: 8***35 Saint Louis, United States
Statistics
Course Work: 4 Pages, Deadline:
2 days
The solution I received is a great one and beyond my expectation. Well done team!
User ID: 8***50 Saint Louis, Somalia
Economics
Home Work: 1 Page, Deadline:
1 day
Expert did Well in terms of reviewing the attached materials on the assignment , and he got 17/20.
User ID: 8***42 Saint Louis, Bahrain
Healthcare
Assignment: 5 Pages, Deadline:
5 days
Excellent work without mistakes or errors. I liked the input about the subject and the number of pages to do a good work
User ID: 3***25 Saint Louis, United States
Programing
Programming: 1 Page, Deadline:
10 days
thanks i had a good grade although it took so many back and forth i hope it wont happen again
User ID: 6***09 Philippines
Healthcare
Assignment: 1 Page, Deadline:
9 hours
Thanks for helping me understand my assignment and also helping me with the write up.
User ID: 8***87 United States
Accounting
Programming: 6.4 Pages, Deadline:
6 days
Excellent Service, Professional and Complete Writing. Will sure contact for further future assignments.
User ID: 8***38 Australia
Finance
Home Work: 2 Pages, Deadline:
3 days
Thankfully, I received one of the best marks awarded for the kind of work given. I am grateful to my assignment help team for their assistance
User ID: 2***85 Ghana
Business Law
Home Work: 1 Page, Deadline:
1 hour
Thank you for your service. Really appreciate that you make my assignment within time
User ID: 7***52 Canada
Management
Assignment: 2 Pages, Deadline:
7 days
Thank you Expert, my professor regraded my work and gave me a good grade this time. but he also mention that going forward i should be more detailed i …
User ID: 2***97 Upper Marlboro, United States
Medical
Programming: 4 Pages, Deadline:
4 days
Really thanks to your efforts. excellent work. It’s well written and well organized and well explained as following instructions. Thanks a lot.
User ID: 6***55 Upper Marlboro, Canada
Marketing
Assignment: 3 Pages, Deadline:
4 days
Well I must say I was delighted by the timelines and great work. The assignment was top notch with excellent results. I got a A+!!!!!
User ID: 8***30 Upper Marlboro, United States
Economics
Home Work: 1 Page, Deadline:
2 days
Great performance by expert which got reflected on the result 9/10. Iam totally satisfied by the performance and result.
User ID: 8***42 Upper Marlboro, Bahrain
Management
Assignment: 6 Pages, Deadline:
1 day
The writer did an amazing job I am pleased with it gave the work to me in time I am happy with it will do more works with them
User ID: 3***40 Chennai, Great Britain
Economics
Programming: 10 Pages, Deadline:
16 days
A legend, a legend, dear expert. The work is excellent and distinct. It contains all the important and accurate details. I thank you for the professio …
User ID: 9***3 Chennai, Kuwait
Nursing
Essay: 8 Pages, Deadline:
12 days
Excellent work! I attained HD on the subject and is one of my highest scores. Thank You!!!
User ID: 6***30 Chennai, Australia
Civil Engineering
Programming: 16 Pages, Deadline:
20 days
was able to submit my assignment early. happy with the service provided. Will use this platform often if i need any other assignments done.
User ID: 7***56 Chennai, Singapore
Nursing
Assignment: 4 Pages, Deadline:
30 days
The paper shows a good grasp of some of the basic points made in the literature, weaving together a number of overlapping ideas.
User ID: 7***96 Chennai, United States
Healthcare
Essay: 4 Pages, Deadline:
18 days
I hope in my next coming assignment you can improve more in order to excellent in A . Thank you for your hard work
User ID: 7***47 Chennai, Singapore
Civil Law
Home Work: 4 Pages, Deadline:
5 hours
Thanks a lot for a quality work I like this expert’s writing structure. I always get help from this site. Customer services is also very good.
User ID: 7***54 Blackburn, Great Britain
Finance
Home Work: 2 Pages, Deadline:
8 days
I will let you know when I receive my grade for the Unit 4 Discussion Board assignment.
User ID: 8***35 Saint Louis, United States
Statistics
Course Work: 4 Pages, Deadline:
2 days
The solution I received is a great one and beyond my expectation. Well done team!
User ID: 8***50 Saint Louis, Somalia
Economics
Home Work: 1 Page, Deadline:
1 day
Expert did Well in terms of reviewing the attached materials on the assignment , and he got 17/20.
User ID: 8***42 Saint Louis, Bahrain
Healthcare
Assignment: 5 Pages, Deadline:
5 days
Excellent work without mistakes or errors. I liked the input about the subject and the number of pages to do a good work
User ID: 3***25 Saint Louis, United States
