Sarah L., a 32-year-old teacher, presents with a progressively worsening, pruritic rash involving her palms, elbows, and behind the knees. The rash has developed over two weeks, presenting as erythematous plaques, lichenification, fissures, and scaling, with increased nocturnal itching. Family history reveals maternal eczema, suggesting a genetic predisposition. Understanding the cellular pathophysiology, genetic contributions, and immune dysregulationunderlying her dermatologic condition is critical to guide diagnosis […]



