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CM9082 Drug Design and Synthesis
Task:
Questions:
Question: 1
Choose one pain reliever you have learnt in this module to answer this question.
(a) Justify two possible side effects of this drug based on its mechanism of action. (6 marks)
(b) Devise one patient scenario (e.g. patient with kidney impairment or food interaction) to explain how the elimination of this drug can be affected and the consequences of the affected drug elimination. (6 marks)
(c) Compare the mechanism of action and pharmacokinetics of this drug with another drug from a different pain reliever pharmacological class by stating their similarities and differences with explanation. (7 marks)
Question 2
Choose ONE drug from the HMG-coA reductase inhibitors pharmacological class to answer this question.
(a) State the therapeutic effect of this drug, and explain how the effect is brought about based on its mechanism of action. (4 marks)
Report format
Write your project report in between 1000 – 2000 words. Any relevant references or citations in the report should be included.
Follow the referencing methods shown below:
• Book
Authors Last name, First initial. (Year published). Title of book. Edition if applicable. Publisher, Page(s).
• Journal Article
Last name, First initial. (Year published). Article title. Journal, Volume (Issue), Page(s).
(b) Comment if this drug should avoid to be taken with grapefruit juice. Explain. (3 marks)
(c) Explain how patients benefit from taking this drug with fibrates. (3 marks)
Question 3
Choose a drug that binds to a receptor at the autonomic nervous system to answer the following questions.
a) State ONE medical condition treated by the drug and explain how the drug acts on the receptor to treat the medical condition. (5 marks)
b) Explain whether the drug is selective towards the receptor, and whether the drug-receptor binding is reversible. Using the drug and its receptor as an example, comment on the impact of selectivity and reversibility of drug-receptor binding. (10 marks)
c) State TWO different routes of administration of the drug. Compare and contrast the pharmacokinetics of these two administration routes, with relation to the drug absorption and distribution to its target site of action. (10 marks)
Question 4
Choose ONE drug from tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs).
With reference to this drug’s binding affinity for the receptor(s) and/or transporter(s) as indicated in Table 1:
(a) Explain how this drug treats depression (3 marks)
(b) State one possible side effect of the drug and explain the cause. (3 marks)
CM9082 Drug Design and Synthesis
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Tellus molestie nunc non blandit massa enim nec dui. Tellus molestie nunc non blandit massa enim nec dui. Ac tortor vitae purus faucibus ornare suspendisse sed nisi. Pharetra et ultrices neque ornare aenean euismod. Pretium viverra suspendisse potenti nullam ac tortor vitae. Morbi quis commodo odio aenean sed. At consectetur lorem donec massa sapien faucibus et. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Duis at tellus at urna condimentum mattis pellentesque. Vivamus at augue eget arcu dictum varius duis at. Justo donec enim diam vulputate ut. Blandit libero volutpat sed cras ornare arcu. Ac felis donec et odio pellentesque diam volutpat commodo. Convallis a cras semper auctor neque. Tempus iaculis urna id volutpat lacus. Tortor consequat id porta nibh.
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Hac habitasse platea dictumst vestibulum rhoncus est pellentesque. Amet dictum sit amet justo donec enim diam vulputate ut. Neque convallis a cras semper auctor neque vitae. Elit at imperdiet dui accumsan. Nisl condimentum id venenatis a condimentum vitae sapien pellentesque. Imperdiet massa tincidunt nunc pulvinar sapien et ligula. Malesuada fames ac turpis egestas maecenas pharetra convallis posuere. Et ultrices neque ornare aenean euismod. Suscipit tellus mauris a diam maecenas sed enim. Potenti nullam ac tortor vitae purus faucibus ornare. Morbi tristique senectus et netus et malesuada. Morbi tristique senectus et netus et malesuada. Tellus pellentesque eu tincidunt tortor aliquam. Sit amet purus gravida quis blandit. Nec feugiat in fermentum posuere urna. Vel orci porta non pulvinar neque laoreet suspendisse interdum. Ultricies tristique nulla aliquet enim tortor at auctor urna. Orci sagittis eu volutpat odio facilisis mauris sit amet.
Tellus molestie nunc non blandit massa enim nec dui. Tellus molestie nunc non blandit massa enim nec dui. Ac tortor vitae purus faucibus ornare suspendisse sed nisi. Pharetra et ultrices neque ornare aenean euismod. Pretium viverra suspendisse potenti nullam ac tortor vitae. Morbi quis commodo odio aenean sed. At consectetur lorem donec massa sapien faucibus et. Nisi quis eleifend quam adipiscing vitae proin sagittis nisl rhoncus. Duis at tellus at urna condimentum mattis pellentesque. Vivamus at augue eget arcu dictum varius duis at. Justo donec enim diam vulputate ut. Blandit libero volutpat sed cras ornare arcu. Ac felis donec et odio pellentesque diam volutpat commodo. Convallis a cras semper auctor neque. Tempus iaculis urna id volutpat lacus. Tortor consequat id porta nibh.
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