Dengue epidemiological characteristic in Kuala Lumpur and Selangor, Malaysia: Mathematics and Computers in Simulation Research Paper, Malaysia

Dengue epidemiological characteristic in Kuala Lumpur and Selangor, Malaysia

Abstract
In the last few decades, dengue remains a leading public health problem in Malaysia. The problem persists with the increasing trend of cases despite the implementation of various interventions by the Ministry of Health Malaysia. The difficulty in eradicating dengue disease throughout the world is related to the complexity of the dengue phenomenon. With no access to a safe, effective, and affordable dengue vaccine, the only intervention strategy is to control the mosquito vector. In reality, data on mosquitoes is limited, and in most cases, the dynamic of mosquitoes is unobservable. In this study, based on the dengue incidence data in Malaysia−Kuala Lumpur and Selangor−from the year 2011 to 2014, a transmission model of type SI-SIR is constructed.

Transmission rates in the two locations are estimated from the data fitting of the dynamic of infected human to dengue incidence. The average infection rate and the estimated average reproduction number for Selangor are estimated to be 0.1674 week−1 and 1.025, respectively. An enclave in Selangor, the capital city Kuala Lumpur has slightly lower average dengue infection rate of 0.1656 week−1 and estimated average reproduction number of 1.014. Further sensitivity analysis indicated that the dengue infection rate is the critical parameter of dengue transmission in Kuala Lumpur and Selangor.

This implies that dengue control strategies should focus on reducing the dengue infection rate. Numerical simulations are also performed to validate the estimated dengue infection rate, to illustrate the dengue dynamics and to determine the effects of dengue control strategies in the two selected locations. The predictive test results of this method also provide good results in capturing the pattern of dengue cases both in Kuala Lumpur and in Selangor. Numerical simulations on instantaneous reproduction number reveal that the instantaneous reproduction number of Kuala Lumpur varies between 0.8 and 1.28 while the instantaneous reproduction number of Selangor varies between 0.7 and 1.2. The insights and results presented in this paper are useful to the relevant authorities in analyzing the effect of mosquito intervention for reducing the prevalence of dengue in Malaysia.

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